In Vitro and In Vivo Neutralizing Efficacy of Monoclonal Antibodies Against Sars-Cov-2 Variants in Kidney Transplant Recipients

Ilies Benotmane; Martin Jungbauer-Groznica; Isabelle Staropoli; Delphine Planas; Océane Dehan; Angela Brisebarre; Etienne Simon-Loriere; Samira Fafi-Kremer; Olivier Schwartz; Timothée Bruel; Sophie Caillard

doi:10.3389/ti.2024.13272

In Vitro and In Vivo Neutralizing Efficacy of Monoclonal Antibodies Against Sars-Cov-2 Variants in Kidney Transplant Recipients

Transpl Int. 2024 Jul 16:37:13272. doi: 10.3389/ti.2024.13272. eCollection 2024.

Authors

Ilies Benotmane^#^{1

2}, Martin Jungbauer-Groznica^#^{3

4

5}, Isabelle Staropoli³, Delphine Planas³, Océane Dehan^{6

7}, Angela Brisebarre^{6

7}, Etienne Simon-Loriere^{6

7}, Samira Fafi-Kremer^{2

8}, Olivier Schwartz^{3

9}, Timothée Bruel^{3

4

9}, Sophie Caillard^{1

2}

Affiliations

¹ Department of Nephrology Dialysis and Transplantation, Strasbourg University Hospital, Strasbourg, France.
² Institut national de la santé et de la recherche médicale (Inserm) UMR S1109, LabEx Transplantex, Fédération de médecine translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
³ Institut Pasteur, Université Paris Cité, Centre national de la recherche scientifique (CNRS) UMR3569, Virus and Immunity Unit, Paris, France.
⁴ Antiviral Activities of Antibodies Group, Université Paris Cité, Centre national de la recherche scientifique (CNRS) UMR3569, Paris, France.
⁵ Université Paris Cité, École Doctorale BioSPC 562, Paris, France.
⁶ Institut Pasteur, Université Paris Cité, G5 Evolutionary Genomics of RNA Viruses, Paris, France.
⁷ National Reference Center for Viruses of Respiratory Infections, Institut Pasteur, Paris, France.
⁸ Department of Virology, Strasbourg University Hospital, Strasbourg, France.
⁹ Vaccine Research Institute, Créteil, France.

^# Contributed equally.

No abstract available

Keywords: COVID-19; SARS-CoV-2; immunocompromised; kidney transplant recipients; monoclonal antibodies; sotrovimab.

Publication types

Letter

MeSH terms

Antibodies, Monoclonal* / therapeutic use
Antibodies, Neutralizing* / immunology
Antibodies, Viral / immunology
COVID-19* / immunology
COVID-19* / prevention & control
Female
Humans
Kidney Transplantation*
Male
Middle Aged
SARS-CoV-2* / immunology
Transplant Recipients

Substances

Antibodies, Neutralizing
Antibodies, Monoclonal
Antibodies, Viral

Supplementary concepts

SARS-CoV-2 variants

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. Work in TB and OS lab is funded by Institut Pasteur, Urgence COVID-19 Fundraising Campaign of Institut Pasteur, the ANR JCJC program (ANR-23-CE15-0039-01), Fondation pour la Recherche Médicale (FRM), ANRS-MIE, the Vaccine Research Institute (ANR-10-LABX-77), Labex IBEID (ANR-10-LABX-62-IBEID), ANR / FRM Flash Covid PROTEO-SARS-CoV-2, Programme Hubert Curien Maimonide, Coronamito, HERA european funding, Sanofi and IDISCOVR. ESL lab is funded by the INCEPTION program (Investissements d’Avenir grant ANR-16-CONV-0005), the NIH PICREID program (Award Number U01AI151758), the HERA European program DURABLE (101102733) and the Labex IBEID (ANR-10-LABX-62-IBEID). The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.