Enhanced skin regeneration and therapeutic delivery using novel diamond-augmented zinc oxide

Xinge Diana Zhang; Claudia Teng; Xuefei Bai; Joyce Teng; Suneel Chilukuri; Amy Lewis; Michael H Gold

doi:10.1111/jocd.16508

Enhanced skin regeneration and therapeutic delivery using novel diamond-augmented zinc oxide

J Cosmet Dermatol. 2024 Dec;23(12):4043-4050. doi: 10.1111/jocd.16508. Epub 2024 Jul 31.

Authors

Xinge Diana Zhang¹, Claudia Teng², Xuefei Bai², Joyce Teng³, Suneel Chilukuri^{4

5}, Amy Lewis⁶, Michael H Gold⁷

Affiliations

¹ School of Applied Sciences and Engineering, Harvard University, Cambridge, Massachusetts, USA.
² B.A.I. Biosciences, Inc., Cambridge, Massachusetts, USA.
³ Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.
⁴ Refresh Dermatology, Houston, Texas, USA.
⁵ Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
⁶ Lewis Dermatology, New York, New York, USA.
⁷ Gold Skin Care Center, Nashville, Tennessee, USA.

Abstract

Background: Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond-Augmented Zinc Oxide (ND-ZnO) technology combines zinc oxide with diamond particles in a unique core-shell structure, offering a multifaceted approach to overall skin health.

Aims: This study evaluates the efficacy of ND-ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.

Patients/methods: In vitro assays assessed wound healing, collagen production, and skin absorption. Human Dermal Fibroblasts (HDFs) were used in scratch wound assays. Collagen synthesis was quantified using enzyme-linked immunosorbent assays (ELISA). Permeation tests were performed on reconstructed human epidermal tissues to evaluate niacinamide absorption. Clinical case studies validated ND-ZnO efficacy in post-CO_₂ laser treatments and Actinic Keratosis removal recovery.

Results: ND-ZnO increased HDF migration by 198% compared to controls. Collagen synthesis assays showed a 71.3% restoration of collagen production in aged HDFs. Skin permeation studies revealed a 203% increase in niacinamide skin absorption with ND-ZnO. Clinical case studies demonstrated faster and more effective healing post-ablative CO₂ laser and significant improvements in Actinic Keratosis recovery.

Conclusions: ND-ZnO technology enhances wound healing, collagen synthesis, and active ingredient delivery, offering substantial benefits for daily skin regeneration and other dermatological applications. This innovative approach holds promise for advancing dermatological therapeutics, providing comprehensive skin care solutions that address both protective and regenerative needs.

Keywords: collagen synthesis; dermatological therapeutics; diamond‐augmented zinc oxide; skin regeneration; wound healing.

MeSH terms

Administration, Cutaneous*
Aged
Cell Movement / drug effects
Cells, Cultured
Collagen*
Female
Fibroblasts* / drug effects
Humans
Lasers, Gas / therapeutic use
Middle Aged
Niacinamide* / administration & dosage
Niacinamide* / pharmacology
Regeneration* / drug effects
Skin / drug effects
Skin Absorption / drug effects
Wound Healing* / drug effects
Zinc Oxide* / administration & dosage

Substances

Zinc Oxide
Niacinamide
Collagen

Grants and funding

B.A.I. Biosciences.