An Autopsy Case of Streptococcus dysgalactiae subsp. equisimilis Infectious Endocarditis Accompanied by Streptococcal Toxic Shock Syndrome

Intern Med. 2024;63(15):2209-2214. doi: 10.2169/internalmedicine.2526-23. Epub 2024 Aug 1.

Abstract

A 66-year-old woman with liver cirrhosis and hemodialysis was referred with a 1-week history of pain and rash on the left lower leg. On an examination, the patient was in shock. She was administered catecholamine support for septic shock and ampicillin/sulbactam for severe cellulitis. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was isolated from the blood culture, and she was diagnosed with streptococcal toxic shock syndrome. Despite therapy, the patient died on day 7 of admission. Infective endocarditis (IE) was diagnosed during an autopsy. Clinicians should be aware that overwhelming SDSE-IE can occur even in the absence of necrotizing fasciitis, especially in immunocompromised patients.

Keywords: Streptococcus dysgalactiae subsp. equisimilis; autopsy; hemodialysis; infectious endocarditis; liver cirrhosis; streptococcal toxic shock syndrome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autopsy*
  • Endocarditis, Bacterial* / complications
  • Endocarditis, Bacterial* / diagnosis
  • Endocarditis, Bacterial* / drug therapy
  • Endocarditis, Bacterial* / microbiology
  • Fatal Outcome
  • Female
  • Humans
  • Shock, Septic* / diagnosis
  • Shock, Septic* / microbiology
  • Streptococcal Infections* / complications
  • Streptococcal Infections* / diagnosis
  • Streptococcal Infections* / microbiology
  • Streptococcus* / isolation & purification

Supplementary concepts

  • Streptococcus dysgalactiae