Advancements in microenvironment-based therapies: transforming the landscape of multiple myeloma treatment

Ke Lu; Wen Wang; Yuntong Liu; Chao Xie; Jiye Liu; Lijie Xing

doi:10.3389/fonc.2024.1413494

Advancements in microenvironment-based therapies: transforming the landscape of multiple myeloma treatment

Front Oncol. 2024 Jul 17:14:1413494. doi: 10.3389/fonc.2024.1413494. eCollection 2024.

Authors

Ke Lu^#¹, Wen Wang^#¹, Yuntong Liu², Chao Xie³, Jiye Liu², Lijie Xing^{1

4}

Affiliations

¹ Department of Lymphoma, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
² Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States.
³ Department of Respiratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
⁴ Key Laboratory of Biopharmaceuticals, Postdoctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Science, Jinan, Shandong, China.

^# Contributed equally.

Abstract

Multiple myeloma (MM) is the most prevalent malignant monoclonal disease of plasma cells. There is mounting evidence that interactions with the bone marrow (BM) niche are essential for the differentiation, proliferation, survival, migration, and treatment resistance of myeloma cells. For this reason, gaining a deeper comprehension of how BM microenvironment compartments interact with myeloma cells may inspire new therapeutic ideas that enhance patient outcomes. This review will concentrate on the most recent findings regarding the mechanisms of interaction between microenvironment and MM and highlight research on treatment targeting the BM niche.

Keywords: bone marrow microenvironment; cellular compartments; multiple myeloma; noncellular compartments; treatment.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grant ZR2021MH072 to LX from Natural Science Foundation of Shandong Province, grant 82200224 to LX from National Natural Science Foundation of China, grant 2023M732124 to LX from China Postdoctoral Science Foundation, and grant 2023HWYQ-115 to LX from Shandong Excellent Youth Science Fund Project (overseas), and grant tsqn202312361to LX from Taishan Scholars Program of Shandong Province.