Disease Course and Treatment Outcomes in Patients With De Novo Small-Cell Lung Cancer and Epidermal Growth Factor Receptor Exon 20 Insertion: Two Case Reports

JCO Precis Oncol. 2024 Jul:8:e2400257. doi: 10.1200/PO.24.00257.

Abstract

We report the first two cases of EGFR exon20ins SCLC, treated with amivantamab and TKIs.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • ErbB Receptors* / genetics
  • Exons* / genetics
  • Female
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Male
  • Middle Aged
  • Small Cell Lung Carcinoma* / drug therapy
  • Small Cell Lung Carcinoma* / genetics
  • Treatment Outcome

Substances

  • ErbB Receptors
  • EGFR protein, human