A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma

BMC Urol. 2024 Aug 2;24(1):165. doi: 10.1186/s12894-024-01532-6.

Abstract

Background: We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).

Methods: We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.

Result: BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).

Conclusion: TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.

Keywords: Immunity; Lymphocytes; Penile squamous cell carcinoma; Tertiary lymphoid structure.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell* / mortality
  • Carcinoma, Squamous Cell* / pathology
  • Humans
  • Male
  • Middle Aged
  • Penile Neoplasms* / mortality
  • Penile Neoplasms* / pathology
  • Prognosis
  • Retrospective Studies
  • Survival Rate
  • Tertiary Lymphoid Structures* / pathology