Mini-colons predict drug toxicity in vitro

Ana Mora-Boza; Andrés J García

doi:10.1016/j.stem.2024.06.013

Mini-colons predict drug toxicity in vitro

Cell Stem Cell. 2024 Aug 1;31(8):1095-1096. doi: 10.1016/j.stem.2024.06.013.

Authors

Ana Mora-Boza¹, Andrés J García²

Affiliations

¹ Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
² Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: andres.garcia@me.gatech.edu.

PMID: 39094538
DOI: 10.1016/j.stem.2024.06.013

Abstract

Mitrofanova et al.¹ engineer a human colonic in vitro model capable of producing an intestinal mucus barrier, with potential applications for predicting drug-induced gastrointestinal toxicity. This improved system paves the way for more accurate and efficient drug development processes.

MeSH terms

Colon* / drug effects
Colon* / pathology
Drug-Related Side Effects and Adverse Reactions
Humans
Intestinal Mucosa / drug effects
Intestinal Mucosa / metabolism
Models, Biological