Reverse Therapy: Impact of Hyperthermia and Rewarming on Newborn Outcomes

Lina F Chalak; Joanne O Davidson; Alistair J Gunn

doi:10.1016/j.clp.2024.04.002

Reverse Therapy: Impact of Hyperthermia and Rewarming on Newborn Outcomes

Clin Perinatol. 2024 Sep;51(3):565-572. doi: 10.1016/j.clp.2024.04.002. Epub 2024 May 16.

Authors

Lina F Chalak¹, Joanne O Davidson², Alistair J Gunn³

Affiliations

¹ Department of Pediatrics, Neonatal-Perinatal Medicine, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA. Electronic address: lina.chalak@utsouthwestern.edu.
² Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand; Department of Paediatrics, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
³ Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

PMID: 39095096
DOI: 10.1016/j.clp.2024.04.002

Abstract

Therapeutic hypothermia is now well established to improve neurodevelopmental outcomes after hypoxic-ischemic encephalopathy (HIE). Although the overall principles of treatment are now well established, many smaller questions are unclear. The potential impact of reversal of hypothermia therapy and the effect of high temperatures on recovery of the neurovascular unit after therapeutic hypothermia for HIE has received relatively little attention. This article will address the effects of hypoxia-ischemia and rewarming and increased temperatures on the neurovascular unit in preclinical and clinical models.

Keywords: Animal models; Hypoxic-ischemic encephalopathy; Pyrexia; Rewarming; Therapeutic hypothermia.

Publication types

Review

MeSH terms

Animals
Humans
Hyperthermia / therapy
Hypothermia, Induced* / methods
Hypoxia-Ischemia, Brain* / therapy
Infant, Newborn
Rewarming* / methods