Resistance to protoporphyrinogen oxidase inhibitors in giant ragweed (Ambrosia trifida)

Pest Manag Sci. 2024 Dec;80(12):6211-6221. doi: 10.1002/ps.8349. Epub 2024 Aug 5.

Abstract

Background: Giant ragweed (Ambrosia trifida L.) is one of the most troublesome weed species in corn (Zea mays L.) and soybean [Glycine max (L.) Merr.] cropping systems. Following numerous reports in 2018 of suspected herbicide resistance in several Ambrosia trifida populations from Wisconsin, our objective was to characterize the response of these accessions to acetolactate synthase (ALS), enolpyruvyl shikimate phosphate synthase (EPSPS), and protoporphyrinogen oxidase (PPO) inhibitors applied POST.

Results: Four accessions (AT1, AT4, AT6, and AT10) exhibited ≥ 50% plant survival after exposure to the cloransulam 3× rate. Two accessions (AT8 and AT10) and one accession (AT2) exhibited ≥ 50% plant survival after exposure to glyphosate and fomesafen 1× rates, respectively. The AT10 accession exhibited multiple resistance to cloransulam and glyphosate. The AT12 accession was 28.8-fold resistant to fomesafen and 3.7-fold resistant to lactofen. A codon change in PPX2 conferring a R98L substitution was identified as the most likely mechanism conferring PPO-inhibitor resistance.

Conclusion: To our knowledge, this is the first confirmed case of PPO-inhibitor resistance in Ambrosia trifida globally and we identified the genetic mutation likely conferring resistance. Proactive and diversified integrated weed management strategies are of paramount importance for sustainable long-term Ambrosia trifida management. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keywords: ALS‐inhibitor resistance; PPO‐inhibitor resistance; glyphosate resistance; herbicide resistance management; target‐site resistance.

MeSH terms

  • Acetolactate Synthase / antagonists & inhibitors
  • Acetolactate Synthase / genetics
  • Ambrosia*
  • Enzyme Inhibitors / pharmacology
  • Herbicide Resistance* / genetics
  • Herbicides* / pharmacology
  • Plant Proteins / genetics
  • Plant Proteins / metabolism
  • Plant Weeds / drug effects
  • Plant Weeds / enzymology
  • Plant Weeds / genetics
  • Protoporphyrinogen Oxidase* / antagonists & inhibitors
  • Protoporphyrinogen Oxidase* / genetics
  • Weed Control

Substances

  • Protoporphyrinogen Oxidase
  • Herbicides
  • Plant Proteins
  • Acetolactate Synthase
  • Enzyme Inhibitors