Emerging roles of the chromatin remodeler MORC2 in cancer metabolism

Bibhukalyan Mohapatra; Suresh B Pakala

doi:10.1007/s12032-024-02464-9

Emerging roles of the chromatin remodeler MORC2 in cancer metabolism

Med Oncol. 2024 Aug 8;41(9):221. doi: 10.1007/s12032-024-02464-9.

Authors

Bibhukalyan Mohapatra¹, Suresh B Pakala²

Affiliations

¹ Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India.
² Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, 500 046, India. pakalasb@uohyd.ac.in.

PMID: 39117768
DOI: 10.1007/s12032-024-02464-9

Abstract

Cancer is characterized by metabolic reprogramming in cancer cells, which is crucial for tumorigenesis. The highly deregulated chromatin remodeler MORC2 contributes to cell proliferation, invasion, migration, DNA repair, and chemoresistance. MORC2 also plays a key role in metabolic reprogramming, including lipogenesis, glucose, and glutamine metabolism. A recent study showed that MORC2-regulated glucose metabolism affects the expression of E-cadherin, a crucial protein in the epithelial-to-mesenchymal transition. This review discusses recent developments in MORC2 regulated cancer cell metabolism and its role in cancer progression.

Keywords: Glucose metabolism; Glutamine metabolism; Lipogenesis; MORC2.

Publication types

Review

MeSH terms

Animals
Chromatin Assembly and Disassembly*
Epithelial-Mesenchymal Transition
Humans
Neoplasms* / genetics
Neoplasms* / metabolism
Neoplasms* / pathology
Transcription Factors* / metabolism

Substances

Transcription Factors
SMARCA2 protein, human