Prevalence, Features, and Outcomes of Type 1 Neovascularization in Eyes with Angioid Streaks

Maria Vittoria Cicinelli; Prithvi Ramtohul; Lorenzo Bianco; Ugo Introini; Francesco Bandello; K Bailey Freund; Maurizio Battaglia Parodi

doi:10.1016/j.oret.2024.08.002

Prevalence, Features, and Outcomes of Type 1 Neovascularization in Eyes with Angioid Streaks

Ophthalmol Retina. 2024 Aug 9:S2468-6530(24)00364-6. doi: 10.1016/j.oret.2024.08.002. Online ahead of print.

Authors

Maria Vittoria Cicinelli¹, Prithvi Ramtohul², Lorenzo Bianco³, Ugo Introini³, Francesco Bandello³, K Bailey Freund⁴, Maurizio Battaglia Parodi³

Affiliations

¹ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: Cicinelli.mariavittoria@hsr.it.
² Ophthalmology Department, Hopital Nord, Aix-Marseille University, Marseille, France.
³ School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁴ Vitreous Retina Macula Consultants of New York, New York, New York; Department of Ophthalmology, New York University Grossman School of Medicine, New York, New York.

PMID: 39127109
DOI: 10.1016/j.oret.2024.08.002

Abstract

Purpose: This study aimed to delineate the characteristics, prevalence, and outcomes of neovascularization (NV), particularly aneurysmal type 1 NV, in patients with angioid streaks (AS) secondary to pseudoxanthoma elasticum (PXE), and to introduce a clinical classification based on multimodal imaging.

Design: Retrospective longitudinal cohort study.

Participants: Eighty-five patients (168 eyes) with AS secondary to PXE at 2 tertiary referral centers.

Methods: Data collection included demographic, medical, and ocular histories. Diagnostic methods comprised fundus photography, autofluorescence, indocyanine green angiography, OCT, and OCT angiography.

Main outcome measures: Prevalence of type 1 NV, visual acuity (VA), risk of exudation.

Results: Type 1 NV was identified in 127 eyes (76%), with 85 of these (67%) showing exclusively type 1 NV. These lesions often originated around the disc, at sites of Bruch membrane dehiscences, and followed the path of AS, extending to the macula in 101 eyes (80%). Despite 65% of type 1 NV remaining nonexudative, 35% evolved into exudative over 5 years, and 11 eyes experienced midperipheral subretinal hemorrhages. Aneurysmal dilations, observed in 57% of eyes, substantially increased exudation risk (hazard ratio = 3.86, P = 0.02). Despite treatment, VA significantly deteriorated in exudative type 1 NV (P = 0.02). Type 2 NV, detected in 42 eyes (33%), often coexisted with type 1 NV and was associated with poorer visual outcomes and higher rates of macular atrophy. A classification of AS was developed, ranging from empty AS (stage 0, no NV) to advanced NV (stage 3, both type 1 and type 2 NV).

Conclusions: Type 1 NV predominates in AS. Although predominantly nonexudative, its progression correlates with substantial visual impairment, similar to the deficits observed with type 2 NV. Aneurysmal type 1 NV poses a significant exudation risk, underscoring the need for vigilant monitoring.

Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Keywords: Aneurysmal; Angioid streaks; Neovascularization; Nonexudative; Pseudoxanthoma elasticum.