Mitochondrial bioenergetic dysfunction linked to myxomatous mitral valve degeneration explored by PBMCs metabolism analysis

Biochim Biophys Acta Bioenerg. 2024 Nov 1;1865(4):149505. doi: 10.1016/j.bbabio.2024.149505. Epub 2024 Aug 16.

Abstract

Impaired mitochondria cause an impressive decrease in ATP production becoming a common condition of cardiovascular diseases. Myxomatous mitral valve disease (MMVD) is characterized by mitochondrial dysfunction. By a non-invasive procedure of metabolism analysis on peripheral blood mononuclear cells, we exploit ex-vivo studies that directly constitute a translational approach to evaluate the cell bioenergetics. Cell ATP production decreased in the presence of MMVD, whereas glycolysis was unaffected. In MMVD, the mitochondrial activity underwent a significant reduction of basal respiration, maximal respiration, and ATP production. Our results depicted a pathological condition of MMVD characterized by cell metabolism deprived of mitochondrial energy support.

Keywords: ATP production; Bioenergetics; Cell metabolism; Mitochondria; Myxomatous mitral valve disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate* / metabolism
  • Aged
  • Energy Metabolism*
  • Female
  • Glycolysis
  • Humans
  • Leukocytes, Mononuclear* / metabolism
  • Male
  • Middle Aged
  • Mitochondria* / metabolism
  • Mitochondria* / pathology
  • Mitral Valve / metabolism
  • Mitral Valve / pathology

Substances

  • Adenosine Triphosphate