Role of pyruvate kinase M2 in regulating sepsis (Review)

Mol Med Rep. 2024 Oct;30(4):185. doi: 10.3892/mmr.2024.13309. Epub 2024 Aug 19.

Abstract

Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.

Keywords: glycolysis; pyruvate kinase M2; sepsis.

Publication types

  • Review

MeSH terms

  • Animals
  • Glycolysis
  • Humans
  • Pyruvate Kinase* / metabolism
  • Sepsis* / metabolism
  • Thyroid Hormone-Binding Proteins
  • Thyroid Hormones / metabolism

Substances

  • Pyruvate Kinase
  • Thyroid Hormone-Binding Proteins
  • Thyroid Hormones

Grants and funding

The present study was supported by Zhejiang Provincial Natural Science Foundation of China (grant no. LQ24H160040), the Zhejiang Medical and Health Science and Technology Project (grant no. 2024KY501), the Jinhua Science and Technology Research Program (grant no. 2022-3-074) and the Jinhua Municipal Central Hospital Young and Middle-aged Science and Technology Project (grant no. JY2022-5-03).