Objective: To investigate the clinical characteristics and prognosis of primary bone marrow lymphoma.
Methods: The clinical data of 6 patients with primary bone marrow lymphoma admitted to Gansu Provincial People's Hospital from February 2011 to March 2023 were collected, and their clinical characteristics and prognosis were retrospectively analyzed and summarized.
Results: The median age of 6 patients was 61(52-74) years old. There were 2 males and 4 females. All patients had fever and abnormal blood routine examination. Physical examination and imaging examination showed no lymphadenopathy, no extranodal lesions in lung, gastrointestinal, liver and spleen, skin, etc. After strict exclusion of systemic lymphoma involvement in the bone marrow, the diagnosis was confirmed by bone marrow examination, 5 cases were primary myeloid diffuse large B-cell lymphoma and 1 case was primary myeloid peripheral T-cell lymphoma (NOS). 1 case abandoned treatment, 5 cases received CHOP-like or combined R regimen， including 1 case of autologous stem cell transplantation. 4 cases died and 2 case survived. The median OS was 5.5 (1-36) months.
Conclusion: The prognosis of primary marrow lymphoma is poor, and bone marrow-related examination is an important means of diagnosis. Diffuse large B-cell lymphoma is the most common histomorphologic and immune subtype, and autologous hematopoietic stem cell transplantation may improve the prognosis.
题目: 原发骨髓淋巴瘤临床特征及预后分析.
目的: 探讨原发骨髓淋巴瘤患者的临床特点及预后。.
方法: 收集2011年2月至2023年3月甘肃省人民医院收治的6例原发骨髓淋巴瘤患者的临床资料，并对其临床特点及预后进行回顾性分析和总结。.
结果: 6例患者的中位发病年龄为61（52-74）岁；男性2例，女性4例，均有血常规异常，5例患者有发热。体格检查及影像学检查无淋巴结肿大，无肺部、胃肠、肝脾、皮肤等结外病变，排除系统性淋巴瘤累及骨髓，依据骨髓相关检查等确诊，其中5例为原发骨髓弥漫大B细胞淋巴瘤，1例为原发骨髓外周T细胞淋巴瘤（非特指型）。1例放弃治疗，5例给予以CHOP样或联合R的方案，其中1例原发骨髓弥漫大B细胞淋巴瘤免疫化疗达完全缓解后行自体造血干细胞移植。4例死亡，2例存活，中位OS为5.5(1-36)个月。.
结论: 原发骨髓淋巴瘤预后差，骨髓相关检查是确诊的重要手段，以弥漫大B细胞淋巴瘤为主，自体造血干细胞移植可能改善预后。.
Keywords: bone marrow； primary； lymphoma； clinical features； prognosis.