Effect of Diabetes Mellitus on the Spectrum of Uropathogens and the Antimicrobial Resistance in Patients with Urinary Tract Infection

Arch Razi Inst. 2024 Feb 1;79(1):92-101. doi: 10.32592/ARI.2024.79.1.92. eCollection 2024 Feb.

Abstract

Patients with diabetes mellitus frequently experience urinary tract infections (UTIs). In the present study, we looked at how glycemic control affects diabetic patients' rates of UTI, the causing pathogens, the presence of multi-drug-resistant (MDR) and extensively drug-resistant organisms, and the infections' relation to diabetes. Diabetes patients' midstream urine samples were included, after collecting and identifying the organisms, disc diffusion antibiotic sensitivity tests were conducted. The HbA1c was measured for all patients. A total of 500 diabetic patients provided urine samples for this study, and 189 (37.2%) of them had UTIs. Compared to 59 patients with managed glycemia, 130 individuals in the uncontrolled glycemic group experienced the most UTI cases. In both diabetic groups, females had a significantly higher prevalence of UTI than males (88.4% and 11.6%, respectively). The most common bacterial isolate, E. coli, displayed 58.4% MDR. Regardless of age or gender, glycemic control in diabetes patients is essential for decreasing UTI rates.

Keywords: Antibacterial resistance; Diabetes mellitus; Glycemia; MDR; UTI; XDR.

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Diabetes Complications / microbiology
  • Diabetes Mellitus / epidemiology
  • Drug Resistance, Bacterial
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Humans
  • Iran / epidemiology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Prevalence
  • Urinary Tract Infections* / drug therapy
  • Urinary Tract Infections* / microbiology

Substances

  • Anti-Bacterial Agents