Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

Chang-Min Lee; Chuan-Hua He; Jin Wook Park; Jae Hyun Lee; Suchitra Kamle; Bing Ma; Bedia Akosman; Roberto Cortez; Emily Chen; Yang Zhou; Erica L Herzog; Changwan Ryu; Xueyan Peng; Ivan O Rosas; Sergio Poli; Carol Feghali Bostwick; Augustine M Choi; Jack A Elias; Chun Geun Lee

doi:10.26508/lsa.202402987

Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

Life Sci Alliance. 2024 Aug 29;7(11):e202402987. doi: 10.26508/lsa.202402987. Print 2024 Nov.

Authors

Chang-Min Lee¹, Chuan-Hua He¹, Jin Wook Park¹, Jae Hyun Lee², Suchitra Kamle¹, Bing Ma¹, Bedia Akosman¹, Roberto Cortez¹, Emily Chen¹, Yang Zhou¹, Erica L Herzog³, Changwan Ryu², Xueyan Peng², Ivan O Rosas⁴, Sergio Poli⁴, Carol Feghali Bostwick⁵, Augustine M Choi⁶, Jack A Elias^{1

7}, Chun Geun Lee⁸

Affiliations

¹ Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
² Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
³ Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
⁴ Brigham and Women's Hospital, Boston, MA, USA.
⁵ Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
⁶ Weill Cornell Medicine Pulmonary and Critical Care Medicine, New York, NY, USA.
⁷ Division of Medicine and Biological Sciences, Brown University, Warren Alpert School of Medicine, Providence, RI, USA.
⁸ Molecular Microbiology and Immunology, Brown University, Providence, RI, USA chun_lee@brown.edu.

Abstract

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.

Publication types

Retraction of Publication