Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018

Zheng Zhang; Miao Zhang; Yingli Qu; Feng Zhao; Saisai Ji; Zheng Li; Bing Wu; Chunxian Lyu; Haocan Song; Qi Sun; Yawei Li; Xu Zhang; Xulin Zheng; Yidan Qiu; Zihan Lu; Hui Fu; Lanjing Xu; Wenli Zhang; Yufei Luo; Fangyu Li; Jiayi Cai; Yuanduo Zhu; Ying Zhu; Zhaojin Cao; Yuebin Lyu; Xiaoming Shi

doi:10.46234/ccdcw2024.186

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018

China CDC Wkly. 2024 Aug 23;6(34):867-871. doi: 10.46234/ccdcw2024.186.

Authors

Zheng Zhang^{1

2}, Miao Zhang¹, Yingli Qu¹, Feng Zhao¹, Saisai Ji¹, Zheng Li¹, Bing Wu^{1

2}, Chunxian Lyu¹, Haocan Song¹, Qi Sun¹, Yawei Li¹, Xu Zhang¹, Xulin Zheng^{1

2}, Yidan Qiu^{1

3}, Zihan Lu^{1

2}, Hui Fu¹, Lanjing Xu^{1

3}, Wenli Zhang¹, Yufei Luo^{1

4}, Fangyu Li^{1

5}, Jiayi Cai¹, Yuanduo Zhu¹, Ying Zhu¹, Zhaojin Cao¹, Yuebin Lyu^{1

6}, Xiaoming Shi^{1

2

6}

Affiliations

¹ China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
² Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing City, Jiangsu Province, China.
³ Department of Big Data in Health Science, School of Public Health, Zhejiang University, Hangzhou City, Zhejiang Province, China.
⁴ Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei City, Anhui Province, China.
⁵ School of Public Health, China Medical University, Shenyang City, Liaoning Province, China.
⁶ National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.

Abstract

What is already known about this topic?: Thallium (Tl) is significantly more toxic than heavy metals such as lead, cadmium, and mercury. However, previous studies examining the relationship between Tl exposure and the risk of chronic kidney disease (CKD) have yielded inconsistent results.

What is added by this report?: The study demonstrated that elevated urinary Tl levels were associated with a higher prevalence of CKD and a reduced estimated glomerular filtration rate (eGFR), particularly among older adults. These findings were consistent in the restricted cubic spline (RCS) analyses.

What are the implications for public health practice?: This study identified Tl as a risk factor for decreased renal function, underscoring the need to enhance surveillance of Tl to mitigate the disease burden of CKD.

Keywords: Thallium; chronic kidney disease; estimate glomerular filtration rate; inflammatory biomarkers.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2024.

Grants and funding

Supported by the National Key Research and Development Program of China (2022YFA0806600) and the National Natural Science Foundation of China (81941023)