Let-7a-5p Inhibits IL-4-induced MUC5AC Expression and Mucus Hypersecretion and Is Transported in Nasal Lavage Extracellular Vesicles

Am J Respir Cell Mol Biol. 2024 Sep;71(3):375-379. doi: 10.1165/rcmb.2023-0268LE.
No abstract available

Publication types

  • Letter

MeSH terms

  • Animals
  • Extracellular Vesicles* / metabolism
  • Humans
  • Interleukin-4* / metabolism
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Mucin 5AC* / genetics
  • Mucin 5AC* / metabolism
  • Mucus* / metabolism
  • Nasal Lavage / methods

Substances

  • Mucin 5AC
  • Interleukin-4
  • MUC5AC protein, human
  • MicroRNAs
  • mirnlet7 microRNA, human