Clinical manifestations and viral kinetics of people with Mpox: A case series during the 2023 outbreak in Taiwan

Kai-Hsiang Chen; Wang-Da Liu; Kuo-Chen Weng; Hui-Hou Chen; Shu-Yuan Ho; Yu-Shan Huang; Tzong-Yow Wu; Guei-Chi Li; Sui-Yuan Chang; Chien-Ching Hung

doi:10.1016/j.jmii.2024.08.008

Clinical manifestations and viral kinetics of people with Mpox: A case series during the 2023 outbreak in Taiwan

J Microbiol Immunol Infect. 2024 Dec;57(6):961-965. doi: 10.1016/j.jmii.2024.08.008. Epub 2024 Aug 23.

Authors

Kai-Hsiang Chen¹, Wang-Da Liu², Kuo-Chen Weng³, Hui-Hou Chen⁴, Shu-Yuan Ho⁵, Yu-Shan Huang⁶, Tzong-Yow Wu⁷, Guei-Chi Li⁸, Sui-Yuan Chang⁹, Chien-Ching Hung¹⁰

Affiliations

¹ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan. Electronic address: ted8019@gmail.com.
² Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan. Electronic address: b95401043@ntu.edu.tw.
³ Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: kuochen@ntuh.gov.tw.
⁴ Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: huihouchen@ntuh.gov.tw.
⁵ Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: yuan62366@ntuh.gov.tw.
⁶ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: b101091021@gmail.com.
⁷ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: retep0102@gmail.com.
⁸ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: ligc2020n@gmail.com.
⁹ Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: sychang@ntu.edu.tw.
¹⁰ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: hcc0401@ntu.edu.tw.

PMID: 39227237
DOI: 10.1016/j.jmii.2024.08.008

Abstract

Monkeypox (Mpox) has emerged as a global threat since 2022. We reported 14 cases of Mpox in 10 people with HIV (PWH) and 4 people without HIV (PWoH), of whom 64.3% had sexually transmitted co-infections. Severe complications of Mpox and prolonged viral shedding might occur in both PWH and PWoH.

Keywords: Acquired immunodeficiency syndrome; Human immunodeficiency virus; Men who have sex with men; Sexually transmitted infection; Tecovirimat.

MeSH terms

Adult
Coinfection* / epidemiology
Coinfection* / virology
Disease Outbreaks*
Female
HIV Infections* / complications
HIV Infections* / drug therapy
HIV Infections* / epidemiology
HIV Infections* / virology
Humans
Male
Middle Aged
Monkeypox virus
Mpox (monkeypox)* / epidemiology
Mpox (monkeypox)* / virology
Taiwan / epidemiology
Viral Load
Virus Shedding*
Young Adult