Hypofractionated Preoperative Radiation Should Not Yet Be Used as Standard of Care for Extremity and Truncal Soft Tissue Sarcoma

J Clin Oncol. 2024 Dec 20;42(36):4240-4245. doi: 10.1200/JCO.24.00238. Epub 2024 Sep 4.

¹ Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA.
² Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX.
³ Radiation Oncology Branch, National Cancer Institute, Bethesda, MD.
⁴ Department of Radiation Oncology, University of Toronto, Princess Margaret Cancer Centre, Toronto, ON, Canada.
⁵ Department of Radiation Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA.
⁶ Department of Radiation Oncology, Royal Marsden Hospital, London, United Kingdom.
⁷ Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI.
⁸ Department of Radiation Oncology, University of California, Irvine, Orange, CA.
⁹ Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
¹⁰ St Luke's Radiation Oncology Network, Rathgar, Dublin, Ireland.
¹¹ Department of Radiotherapy, Leiden University Medical Center, Amsterdam, the Netherlands.
¹² Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York City, NY.
¹³ Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Abstract

Hypofractionated radiation therapy regimens should not be used as standard of care for localized soft tissue sarcoma.