Abstract
Human blood platelets show a sodium and temperature dependent uptake of gamma-aminobutyric acid (GABA) and other neuroactive amino acids. The most potent inhibitors tested of platelet GABA uptake were taurine and beta-alanine, while nipecotic acid and cis-3-aminocyclohexanecarboxylic acid were relatively weak inhibitors. These results suggest GABA is transported by a beta-amino acid uptake process in human platelets. Thus, platelet GABA uptake may more closely resemble glial rather than neuronal uptake.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / pharmacology
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Amino Acids, Cyclic*
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Blood Platelets / drug effects
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Blood Platelets / metabolism*
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Central Nervous System / metabolism*
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Cyclohexanecarboxylic Acids / pharmacology
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Humans
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Kinetics
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Nipecotic Acids / pharmacology
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Proline* / analogs & derivatives*
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Sodium / pharmacology
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Taurine / pharmacology
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beta-Alanine / pharmacology
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gamma-Aminobutyric Acid / blood*
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gamma-Aminobutyric Acid / metabolism
Substances
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Amino Acids
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Amino Acids, Cyclic
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Cyclohexanecarboxylic Acids
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Nipecotic Acids
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beta-Alanine
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Taurine
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nipecotic acid
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3-aminocyclohexanecarboxylic acid
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gamma-Aminobutyric Acid
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Proline
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Sodium
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homoproline