Airineme-Mediated Intercellular Communication

Results Probl Cell Differ. 2024:73:147-154. doi: 10.1007/978-3-031-62036-2_7.

Abstract

Intercellular communication is indispensable across multicellular organisms, and any aberration in this process can give rise to significant anomalies in developmental and homeostatic processes. Thus, a comprehensive understanding of its mechanisms is imperative for addressing human health-related concerns. Recent advances have expanded our understanding of intercellular communication by elucidating additional signaling modalities alongside established mechanisms. Notably, cellular protrusion-mediated long-range communication, characterized by physical contact through thin and elongated cellular protrusions between cells involved in signal transmission and reception, has emerged as a significant intercellular signaling paradigm. This chapter delves into the exploration of a signaling cellular protrusion termed 'airinemes,' discovered in the zebrafish skin. It covers their identified signaling roles and the cellular and molecular mechanisms that underpin their functionality.

Keywords: Airinemes; Cellular protrusions; Cytonemes; Intercellular communication; Macrophages; Melanophores; Metaphocytes; Notch; Pigment cells; Xanthophores; Zebrafish.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication* / physiology
  • Humans
  • Signal Transduction / physiology
  • Zebrafish*