Neighbor's feedback helps macrophages learn tolerance in the gut

Giuseppe Giuliani; Jayajit Das

doi:10.1016/j.immuni.2024.08.012

Neighbor's feedback helps macrophages learn tolerance in the gut

Immunity. 2024 Sep 10;57(9):2002-2004. doi: 10.1016/j.immuni.2024.08.012.

Authors

Giuseppe Giuliani¹, Jayajit Das²

Affiliations

¹ Department of Physics, The Ohio State University, Columbus, OH, USA; Steve and Cindy Rasmussen Institute for Genomic Medicine, The Abigail Wexner Research Institute at the Nationwide Children's Hospital, Columbus, OH, USA.
² Steve and Cindy Rasmussen Institute for Genomic Medicine, The Abigail Wexner Research Institute at the Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA; Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address: jayajit@gmail.com.

PMID: 39260351
DOI: 10.1016/j.immuni.2024.08.012

Abstract

Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).

MeSH terms

Animals
Epithelial Cells / immunology
Feedback, Physiological
Humans
Immune Tolerance* / immunology
Intestinal Mucosa* / immunology
Intestines / immunology
Macrophages* / immunology