Pediatric Primary Dural Lymphoblastic B-cell Lymphoma Presenting as Hematoma in the Frontoparietal Region: A Case Report

J Pediatr Hematol Oncol. 2024 Oct 1;46(7):380-382. doi: 10.1097/MPH.0000000000002929. Epub 2024 Aug 30.

Abstract

Lymphomas originating from the meninges without brain or systemic involvement represent an extremely rare type of primary central nervous system lymphomas. Here, we report a case of primary dural lymphoma in a 3-year-old boy who was brought to the hospital due to headache, nausea, and vomiting episodes ongoing for several days. An acute hematoma in the right frontoparietal region was detected on a brain CT scan. The patient underwent surgery to remove the hematoma, which was then sent for pathologic examination. The pathology report revealed lymphoblastic B-cell lymphoma with a Ki-67 proliferation index of 80%. Radiologic and FDG-PET/CT imaging, as well as bone marrow examination, did not reveal any systemic disease. The NHL BFM 2012 lymphoblastic lymphoma treatment protocol was started and successfully completed. The patient has been followed for ~2 years and is still alive and disease-free. This is the first case of pediatric primary dural lymphoblastic B-cell lymphoma ever reported in the literature.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child, Preschool
  • Dura Mater / diagnostic imaging
  • Dura Mater / pathology
  • Hematoma* / etiology
  • Hematoma* / pathology
  • Humans
  • Male
  • Meningeal Neoplasms / complications
  • Meningeal Neoplasms / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology