Development of in vitro biopharmaceutics tools for predicting the bioavailability of subcutaneously injected monoclonal antibodies and oligonucleotides

Expert Opin Drug Deliv. 2024 Sep;21(9):1307-1310. doi: 10.1080/17425247.2024.2403469. Epub 2024 Sep 21.
No abstract available

Keywords: Absorption; Biologics; GalNAc; Pharmacokinetics; Physiologically based biopharmaceutics modeling (PBBM); SCISSOR; SiRNA; mAbs.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Antibodies, Monoclonal* / administration & dosage
  • Antibodies, Monoclonal* / pharmacokinetics
  • Biological Availability*
  • Biopharmaceutics*
  • Drug Development / methods
  • Humans
  • Injections, Subcutaneous
  • Oligonucleotides* / administration & dosage
  • Oligonucleotides* / pharmacokinetics

Substances

  • Antibodies, Monoclonal
  • Oligonucleotides