Torsemide in Edema Associated with Chronic Kidney Disease

J Assoc Physicians India. 2024 Sep;72(9S):27-31. doi: 10.59556/japi.72.0674.

Abstract

Torsemide is a loop diuretic used to manage edema associated with chronic kidney disease (CKD) and acute kidney injury (AKI). It acts by inhibiting sodium and chloride ions reabsorption in the ascending limb of the loop of Henle, thereby increasing urine output and reducing fluid accumulation. Compared to other diuretics, torsemide has an extended duration of action, higher bioavailability, and its elimination route is primarily through the hepatic route, making it effective in patients with CKD and AKI. Clinical studies indicate that torsemide can improve symptoms of fluid overload and potentially enhance renal function.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / drug therapy
  • Edema* / drug therapy
  • Edema* / etiology
  • Humans
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / drug therapy
  • Sodium Potassium Chloride Symporter Inhibitors* / pharmacology
  • Sodium Potassium Chloride Symporter Inhibitors* / therapeutic use
  • Torsemide* / pharmacology
  • Torsemide* / therapeutic use

Substances

  • Sodium Potassium Chloride Symporter Inhibitors
  • Torsemide