The Use of Multiple Medications During Pregnancy Among an Ethnically Diverse Population in South-Eastern Melbourne: A Retrospective Analysis to Explore Potential Risks and Complications

Yitayeh Belsti; Aya Mousa; Hannah Jackson; Lisa J Moran; Kirsten R Palmer; Raja Ram Dhungana; Emily Callander; Daniel Lorber Rolnik; Helena Teede; Joanne Enticott

doi:10.1007/s40264-024-01482-w

The Use of Multiple Medications During Pregnancy Among an Ethnically Diverse Population in South-Eastern Melbourne: A Retrospective Analysis to Explore Potential Risks and Complications

Drug Saf. 2024 Sep 20. doi: 10.1007/s40264-024-01482-w. Online ahead of print.

Authors

Yitayeh Belsti¹, Aya Mousa¹, Hannah Jackson², Lisa J Moran¹, Kirsten R Palmer^{3

4

5}, Raja Ram Dhungana¹, Emily Callander², Daniel Lorber Rolnik^{3

4}, Helena Teede^{1

3}, Joanne Enticott⁶

Affiliations

¹ Monash Centre for Health Research and Implementation (MCHRI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Level 1, 43-51 Kanooka Grove, Clayton, Melbourne, VIC, 3168, Australia.
² Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
³ Monash Health, Melbourne, VIC, Australia.
⁴ Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
⁵ The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
⁶ Monash Centre for Health Research and Implementation (MCHRI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Level 1, 43-51 Kanooka Grove, Clayton, Melbourne, VIC, 3168, Australia. joanne.enticott@monash.edu.

PMID: 39302513
DOI: 10.1007/s40264-024-01482-w

Abstract

Background and objective: Medication use is increasing to treat both pre-existing and pregnancy-related medical conditions or complications. This study aims to investigate factors associated with multiple medication use during pregnancy, as well as any increased risk of pregnancy complications for women taking multiple medications.

Methods: A retrospective analysis of routinely collected medical records of singleton pregnant women was conducted in Southeast Melbourne, Australia, between 2016 and 2021. Self-reported medication use was recorded as part of routine medical care, starting from the first antenatal booking appointment and continuing for every subsequent antenatal appointment until birth. Multimorbidity was defined as having two or more medical conditions. Logistic regression was used to assess factors influencing multiple medication use (defined as taking two or more non-supplemental medications at any stage of pregnancy) and associations with pregnancy complications.

Results: Of 48,502 participants, 34.9% used one medication, while 11.7% used multiple medications. Women of older age (30-34, 35-39, and ≥ 40 years), higher body mass index (25.0-29.9 kg/m² and ≥ 30 kg/m²), born in Australasia and Oceania, higher socioeconomic status, and multimorbidity were more likely to use multiple medications during pregnancy. Women taking multiple medications had a higher risk of preterm and caesarean deliveries, fetal death, and neonatal admissions to intensive care. Sensitivity analyses exploring different morbidity categories produced no changes to findings.

Conclusions: Medication use during pregnancy is prevalent, with many pregnant mothers taking multiple medications. Given the rising maternal age, body mass index, and morbidities in pregnancy, the use of medications during pregnancy is increasing. Such use correlates with an increased chance of adverse pregnancy outcomes. In the context of limited trials on the safety and efficacy of medications in pregnancy, timely harnessing of the information available within routine medical records for post-marketing surveillance is important.