We examined the emergence and characteristics of oxacillinase-484-producing Enterobacterales in France during 2012-2023. Genomic analysis identified 2 predominant sequence types in Escherichia coli: ST410 and ST1722. Plasmid analysis revealed that blaOXA-484 genes were carried mostly on an IncX3-type plasmid associated with genetic elements including insertion sequences IS3000 and ISKpn19.
Keywords: Antimicrobial resistance; E. coli ST1722; E. coli ST410; Enterobacterales; Escherichia coli; France; OXA-484; bacteria; carbapenemase; epidemiology; oxacillinase.