Lessons on neurodegeneration and aging from the Lagoon of Venice: the marine invertebrate Botryllus schlosseri

Tommaso Bocci; Chiara Anselmi; Federico La Torre; Emanuela De Lisa; Giacomo Sabbadin; Matteo Guidetti; Natale Maiorana; Alberto Priori; Lucia Manni

doi:10.1093/braincomms/fcae257

Lessons on neurodegeneration and aging from the Lagoon of Venice: the marine invertebrate Botryllus schlosseri

Brain Commun. 2024 Sep 25;6(5):fcae257. doi: 10.1093/braincomms/fcae257. eCollection 2024.

Authors

Tommaso Bocci^{1

2}, Chiara Anselmi^{3

4

5}, Federico La Torre⁶, Emanuela De Lisa⁶, Giacomo Sabbadin⁶, Matteo Guidetti^{1

2}, Natale Maiorana^{1

2}, Alberto Priori^{1

2}, Lucia Manni⁶

Affiliations

¹ 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Department of Health Sciences, University of Milan, 20142 Milan, Italy.
² Clinical Neurology Unit, 'Azienda Socio-Sanitaria Territoriale Santi Paolo E Carlo', Department of Health Sciences, University of Milan, 20142 Milan, Italy.
³ Hopkins Marine Station, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Pacific Grove, CA 93950, USA.
⁴ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁵ Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
⁶ Dipartimento di Biologia, Università degli Studi di Padova, 35131 Padua, Italy.

Abstract

In this work, the authors proposed a novel and interesting animal model for studying human neurodegenerative diseases, Botryllus schlosseri, a small invertebrate inhabiting temperate seas worldwide, which shares remarkable similarities with mammals in the expression of genes involved in pathological aging.