Health State Utility is Substantially Reduced With an Increasing Burden of Patient-Reported Symptoms in Eosinophilic Esophagitis

Cary C Cotton; Mousumi Biswas; Evan S Dellon

doi:10.14309/ajg.0000000000003106

Health State Utility is Substantially Reduced With an Increasing Burden of Patient-Reported Symptoms in Eosinophilic Esophagitis

Am J Gastroenterol. 2024 Sep 27. doi: 10.14309/ajg.0000000000003106. Online ahead of print.

Authors

Cary C Cotton¹, Mousumi Biswas², Evan S Dellon¹

Affiliations

¹ Department of Medicine, Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
² Global Health Economics and Outcomes Research, Bristol Myers Squibb, Princeton, New Jersey, USA .

PMID: 39329387
DOI: 10.14309/ajg.0000000000003106

Abstract

Introduction: We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters.

Methods: In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index.

Results: In 51 adults with EoE, the mean utility was 0.91 (95% CI 0.86, 0.95). Utility was numerically worse in patients with dilation or a smaller stricture diameter. With each ten-point improvement in EoE Symptom Activity Index, utility increased by 0.03 (95% CI 0.01, 0.05).

Discussion: EoE is associated with reduced health state utility, with symptoms most strongly predicting valuation.

Grants and funding

Bristol-Myers Squibb