Neuropsychological Manifestations of Multiple Sclerosis

Laura M Hancock; Stephen M Rao; Rachel Galioto

doi:10.1016/j.ncl.2024.05.010

Neuropsychological Manifestations of Multiple Sclerosis

Neurol Clin. 2024 Nov;42(4):835-847. doi: 10.1016/j.ncl.2024.05.010. Epub 2024 Jun 14.

Authors

Laura M Hancock¹, Stephen M Rao², Rachel Galioto³

Affiliations

¹ Center for General Neurology, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, S31, Cleveland, OH 44195, USA. Electronic address: hancocl4@ccf.org.
² Schey Center for Cognitive Neuroimaging, Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, U10, Cleveland, OH 44195, USA.
³ Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, U10, Cleveland, OH 44195, USA.

PMID: 39343478
DOI: 10.1016/j.ncl.2024.05.010

Abstract

This review article summarizes the literature on the cognitive impairment seen amongst people with multiple sclerosis (MS) and how that impairment can impact not only their lives but also how their care needs to be managed. Recommendations regarding screening and monitoring of cognitive issues are reviewed, as well as how common comorbidities can further impact cognition. The current literature with respect to treatment options is also summarized. Finally, the article reviews the literature on some special populations living with MS.

Keywords: Cognition; Multiple sclerosis; Neuropsychological evaluation; Processing speed.

Publication types

Review

MeSH terms

Cognitive Dysfunction / diagnosis
Cognitive Dysfunction / etiology
Humans
Multiple Sclerosis* / complications
Multiple Sclerosis* / psychology
Neuropsychological Tests