Crosstalk between human endogenous retroviruses and exogenous viruses

Edoardo Pizzioli; Antonella Minutolo; Emanuela Balestrieri; Claudia Matteucci; Gkikas Magiorkinis; Branka Horvat

doi:10.1016/j.micinf.2024.105427

Crosstalk between human endogenous retroviruses and exogenous viruses

Microbes Infect. 2024 Sep 28:105427. doi: 10.1016/j.micinf.2024.105427. Online ahead of print.

Authors

Edoardo Pizzioli¹, Antonella Minutolo², Emanuela Balestrieri², Claudia Matteucci², Gkikas Magiorkinis³, Branka Horvat⁴

Affiliations

¹ CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, France.
² Department of Experimental Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
³ Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁴ CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, France. Electronic address: branka.horvat@inserm.fr.

PMID: 39349096
DOI: 10.1016/j.micinf.2024.105427

Abstract

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections of human germ-line cells, which are mostly silenced during evolution, but could be de-repressed and play a pathological role. Infection with some exogenous viruses, including herpesviruses, HIV-1 and SARS-CoV-2, was demonstrated to induce the expression of HERV RNAs and proteins.