Pulmonary artery mass with PIK3CA mutation after orthotopic heart transplantation

J Cardiothorac Surg. 2024 Oct 1;19(1):558. doi: 10.1186/s13019-024-03090-2.

Abstract

Background: Patients can develop de novo malignancies following orthotopic heart transplantation. However, vascular tumors are not commonly described in this population.

Case presentation: We present a 69-year-old female with a history of orthotopic heart transplantation for chemotherapy-induced cardiomyopathy who developed an incidental pulmonary artery mass six years after her transplantation. Given concerns for malignancy, the patient underwent an operative excisional biopsy through a left anterior mini-thoracotomy with femoral artery and vein cannulation for cardiopulmonary bypass. The mass was determined to be a non-malignant vascular overgrowth with PIK3CA mutation.

Conclusion: We present the case of an unusual pulmonary artery mass with PIK3CA mutation found in a post heart transplant patient. We were able to spare her the morbidity of a redo-sternotomy by excising the mass via a minimally invasive left anterior thoracotomy approach.

Keywords: Heart transplantation; Minimally invasive surgery; Pulmonary artery mass.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Class I Phosphatidylinositol 3-Kinases* / genetics
  • Female
  • Heart Transplantation* / adverse effects
  • Humans
  • Mutation*
  • Pulmonary Artery* / surgery
  • Vascular Neoplasms / genetics
  • Vascular Neoplasms / surgery

Substances

  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human