The association between the triglyceride-glucose index and bone turnover markers in osteoporotic fractures patients aged 50 and above who are hospitalized for surgical intervention: a retrospective cross-sectional study

Front Endocrinol (Lausanne). 2024 Sep 18:15:1418271. doi: 10.3389/fendo.2024.1418271. eCollection 2024.

Abstract

Objective: To evaluate the correlation between the triglyceride-glucose (TyG) index and bone turnover markers (BTMs) in osteoporotic fractures (OPFs) patients hospitalized for surgical intervention.

Methods: A retrospective cross-sectional study was conducted on 3558 OPFs patients hospitalized for surgical intervention between January 2017 and July 2022. The study obtained baseline values for various biomarkers and covariates, including fasting blood glucose, β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type 1 N-terminal propeptide (P1NP), triglycerides, age, sex, body mass index, smoking, drinking, low-density lipoprotein, high-density lipoprotein, aspartate aminotransferase, uric acid, the score of American society of anesthesiologists, homocysteine, parathyroid hormone, apolipoprotein B, apolipoprotein A, magnesium, phosphorus and calcium. Multiple linear regression, curve fitting, threshold effects, and subgroup analyses were also applied.

Results: After adjusting for covariates in the regression analysis, the results revealed a negative correlation between β-CTX and P1NP levels and the baseline TyG index. Specifically, a one-unit increase in the TyG index was associated with a reduction in β-CTX levels of -0.06 (95% CI: -0.10, -0.01; P-value = 0.012) and a reduction in P1NP levels of -4.70 (95% CI: -9.30, -0.09; P-value = 0.046). Additionally, the inflection points for the nonlinear correlation between the TyG index and β-CTX and P1NP were found to be K = 6.31 and K = 6.63, respectively.

Conclusion: The study demonstrated a negative, non-linear relationship among the TyG index, β-CTX and P1NP in OPFs patients hospitalized for surgical intervention. These findings suggest that elevated TyG index levels may adversely affect bone turnover, potentially contributing to the progression of OP.

Keywords: BTMs; P1NP; TyG index; osteoporotic fractures; β-CTX.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers* / blood
  • Blood Glucose* / metabolism
  • Bone Remodeling* / physiology
  • Collagen Type I / blood
  • Cross-Sectional Studies
  • Female
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Osteoporotic Fractures* / blood
  • Osteoporotic Fractures* / surgery
  • Peptide Fragments / blood
  • Peptides
  • Procollagen / blood
  • Retrospective Studies
  • Triglycerides* / blood

Substances

  • Biomarkers
  • Triglycerides
  • Blood Glucose
  • Collagen Type I
  • collagen type I trimeric cross-linked peptide
  • procollagen Type I N-terminal peptide
  • Procollagen
  • Peptide Fragments
  • Peptides

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study was supported by National Natural Science Foundation of China (CN) (82172441), Suzhou City Major Disease Multicenter Clinical Research Project (CN) (DZXYJ202312), Special Funding for Jiangsu Province Science and Technology Plan (Key Research and Development Program for Social Development) (CN) (BE2023737) and Gusu Health Talent Plan Scientific Research Project (CN) (GSWS2022109).