First contact(in): The complete structure of contactin 2

Lucas M P Chataigner; Bert J C Janssen

doi:10.1016/j.str.2024.09.003

First contact(in): The complete structure of contactin 2

Structure. 2024 Oct 3;32(10):1545-1547. doi: 10.1016/j.str.2024.09.003.

Authors

Lucas M P Chataigner¹, Bert J C Janssen²

Affiliations

¹ Department of Computational Biology, Institut Pasteur, Université Paris Cité, 25-28 Rue du Dr Roux, 75015 Paris, France.
² Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands. Electronic address: b.j.c.janssen@uu.nl.

PMID: 39366335
DOI: 10.1016/j.str.2024.09.003

Abstract

In this issue of Structure, Fan et al.¹ report the structure of the full contactin 2 ectodomain, representing the first for the contactin family. The work reveals six immunoglobulin domains are essential for intercellular interactions, explores differences in proposed contactin 2 homodimerization mechanisms, and provides an updated model for contactin 2 organization on and between cells.

MeSH terms

Contactin 2* / chemistry
Contactin 2* / metabolism
Immunoglobulin Domains
Models, Molecular
Protein Multimerization

Substances

Contactin 2