Waves of change: Dynamic actomyosin networks in embryonic development

Abstract

As animals develop, molecules, cells, and cell ensembles move in beautifully orchestrated choreographies. Movement at each of these scales requires generation of mechanical force. In eukaryotic cells, the actomyosin cytoskeleton generates mechanical forces. Continuous advances in in vivo microscopy have enabled visualization and quantitative assessment of actomyosin dynamics and force generation, within and across cells, in living embryos. Recent studies reveal that actomyosin networks can form periodic waves in vivo. Here, we highlight contributions of actomyosin waves to molecular transport, cell movement, and cell coordination in developing embryos.