Phosphination of aryl/alkyl bromides via Mn-mediated reductive C-P coupling

Chem Commun (Camb). 2024 Oct 24;60(86):12549-12552. doi: 10.1039/d4cc04750h.

Abstract

Mn-mediated reductive cross-coupling of organic bromides with 2-bromo-1,3,2-diazaphospholene was developed for efficient construction of C-P bonds under mild conditions. Mechanistic studies suggested that bromides are activated by in situ formed bis-diazaphospholene via hybrid radical and polar mechanisms.