Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study

Am J Gastroenterol. 2024 Dec 1;119(12):2532-2539. doi: 10.14309/ajg.0000000000003035. Epub 2024 Sep 4.

Abstract

Introduction: Risk factors for serrated polyps (SPs) are not well understood.

Methods: Multivariable analyses of data from a multicenter colonoscopy-based study estimated odds ratios for having either a sessile serrated lesion or traditional serrated adenoma according to participant characteristics.

Results: Six thousand seventy-eighty participants were included in the analyses (565 with either a sessile serrated lesion or traditional serrated adenoma). White race was associated with a higher risk of SPs compared with Black race (adjusted odds ratio 4.64, 95% confidence interval 1.89-11.41). Obesity and current smoking were also associated with a higher risk of SPs.

Discussion: White race, smoking, and obesity are risk factors for precancerous SPs.

Publication types

  • Multicenter Study

MeSH terms

  • Adenoma* / diagnosis
  • Adenoma* / epidemiology
  • Adenoma* / pathology
  • Adult
  • Aged
  • Colonic Polyps* / diagnosis
  • Colonic Polyps* / epidemiology
  • Colonic Polyps* / pathology
  • Colonoscopy* / statistics & numerical data
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obesity* / complications
  • Obesity* / epidemiology
  • Odds Ratio
  • Precancerous Conditions / epidemiology
  • Precancerous Conditions / pathology
  • Risk Factors
  • Smoking / adverse effects
  • Smoking / epidemiology
  • White