Sevelamer

Excerpt

Chronic kidney disease (CKD) is a complex condition that poses significant challenges, profoundly affecting patients' quality of life and mortality. This impact is secondary to numerous manifestations stemming from the progressive decline in glomerular filtration rate and its associated consequences. In advanced CKD, phosphate clearance decreases, leading to its accumulation in the body. While some phosphate originates endogenously, most is absorbed through the gastrointestinal (GI) tract. The concept of using phosphate binders emerged in the mid-twentieth century, with various agents such as aluminum-based, calcium-based, and lanthanum-based binders being used. However, due to adverse effects, particularly in the CKD population, the search for more effective medications continued.