Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma

Karen Alpen; Robert J Maclnnis; Claire M Vajdic; John Lai; James G Dowty; Eng-Siew Koh; Elizabeth Hovey; Rosemary Harrup; Tuong L Nguyen; Shuai Li; David Joseph; Geza Benke; Pierre-Antoine Dugué; Melissa C Southey; Graham G Giles; Anna K Nowak; Katharine J Drummond; Daniel F Schmidt; John L Hopper; Miroslaw K Kapuscinski; Enes Makalic

doi:10.1158/2767-9764.CRC-24-0385

Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma

Cancer Res Commun. 2024 Nov 1;4(11):2933-2946. doi: 10.1158/2767-9764.CRC-24-0385.

Authors

Karen Alpen¹, Robert J Maclnnis^{1

2}, Claire M Vajdic³, John Lai^{1

4}, James G Dowty¹, Eng-Siew Koh^{5

6

7}, Elizabeth Hovey^{8

9}, Rosemary Harrup^{10

11}, Tuong L Nguyen¹, Shuai Li^{1

12

13

14}, David Joseph¹⁵, Geza Benke¹⁶, Pierre-Antoine Dugué^{1

2

12}, Melissa C Southey^{2

12

17}, Graham G Giles^{1

2

12}, Anna K Nowak¹⁸, Katharine J Drummond^{19

20}, Daniel F Schmidt^{1

21}, John L Hopper¹, Miroslaw K Kapuscinski¹, Enes Makalic^{1

21}

Affiliations

¹ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia.
² Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
³ The Kirby Institute, UNSW Sydney, Sydney, Australia.
⁴ Australian Genome Research Facility, St Lucia, Australia.
⁵ South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, Australia.
⁶ Liverpool and Macarthur Cancer Therapy Centres, Liverpool Hospital, Liverpool, Australia.
⁷ Ingham Institute for Applied Medical Research, Liverpool, Australia.
⁸ Nelune Comprehensive Cancer Centre, Prince of Wales Hospital, Sydney, Australia.
⁹ Faculty of Medicine, Prince of Wales Clinical School UNSW Sydney, Sydney, Australia.
¹⁰ Royal Hobart Hospital, Hobart, Australia.
¹¹ University of Tasmania, Hobart, Australia.
¹² Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.
¹³ Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
¹⁴ Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
¹⁵ Department of Medicine and Surgery, The University of Western Australia, Perth, Australia.
¹⁶ School of Public Health and Preventative Medicine, Monash University, Clayton, Australia.
¹⁷ Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Australia.
¹⁸ Medical School, University of Western Australia, Crawley, Australia.
¹⁹ Department of Neurosurgery, Royal Melbourne Hospital, Parkville, Australia.
²⁰ Department of Surgery, University of Melbourne, Parkville, Australia.
²¹ Faculty of Information Technology, Monash University, Clayton, Australia.

Abstract

Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-specific analysis in future glioma research.

MeSH terms

Brain Neoplasms / genetics
Female
Genetic Predisposition to Disease*
Genome-Wide Association Study*
Glioma* / genetics
Humans
Male
Polymorphism, Single Nucleotide

Abstract

MeSH terms

Grants and funding