Biologics in Asthma: Potential to Achieve Clinical Remission

Immunol Allergy Clin North Am. 2024 Nov;44(4):725-736. doi: 10.1016/j.iac.2024.08.004. Epub 2024 Sep 6.

Abstract

Establishing a universal definition for asthma remission has the potential to improve asthma outcomes and advance research. However, there is still no consensus definition despite broad multidisciplinary efforts to achieve this goal. This study explores the evolving concept of asthma remission, emphasizing the potential of biologics to achieve this state. We will discuss various proposed definitions of asthma remission, international guidelines, and studies evaluating the effectiveness of biologics at achieving clinical remission. We highlight the need for a consensus definition of asthma remission to standardize treatment goals and improve patient outcomes.

Keywords: Asthma; Benralizumab; Biologics; Dupilumab; Mepolizumab; Remission; Tezepelumab.

Publication types

  • Review

MeSH terms

  • Anti-Asthmatic Agents* / therapeutic use
  • Asthma* / diagnosis
  • Asthma* / drug therapy
  • Asthma* / therapy
  • Biological Products* / therapeutic use
  • Humans
  • Practice Guidelines as Topic
  • Remission Induction*
  • Treatment Outcome

Substances

  • Biological Products
  • Anti-Asthmatic Agents