Six new phenolic glycosides from the roots of Scrophularia ningpoensis

Fitoterapia. 2024 Dec:179:106258. doi: 10.1016/j.fitote.2024.106258. Epub 2024 Oct 16.

Abstract

Six new phenolic glycosides (1-6) and thirteen known compounds (7-19) were isolated from the roots of Scrophularia ningpoensis. Their structures were determined through comprehensive analyses of the physicochemical properties and spectroscopic data (1D NMR, 2D NMR, and HR-ESI-MS). The anti-inflammatory potential of all compounds was evaluated by determining their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW 264.7 macrophage cells. In addition, the cytotoxicity of all compounds on HepG2, 4T1 and A549 cell lines was also evaluated.

Keywords: Anti-inflammatory; Chemical constituents; Phenolic glycosides; Scrophularia ningpoensis Hemsl..

MeSH terms

  • A549 Cells
  • Animals
  • Anti-Inflammatory Agents* / isolation & purification
  • Anti-Inflammatory Agents* / pharmacology
  • Cell Line, Tumor
  • China
  • Glycosides* / chemistry
  • Glycosides* / isolation & purification
  • Glycosides* / pharmacology
  • Hep G2 Cells
  • Humans
  • Mice
  • Molecular Structure
  • Nitric Oxide* / metabolism
  • Phenols* / chemistry
  • Phenols* / isolation & purification
  • Phenols* / pharmacology
  • Phytochemicals* / isolation & purification
  • Phytochemicals* / pharmacology
  • Plant Roots* / chemistry
  • RAW 264.7 Cells
  • Scrophularia* / chemistry

Substances

  • Glycosides
  • Phenols
  • Phytochemicals
  • Nitric Oxide
  • Anti-Inflammatory Agents