Cellular senescence: A new perspective on the suppression of periodontitis (Review)

Mol Med Rep. 2024 Dec;30(6):238. doi: 10.3892/mmr.2024.13362. Epub 2024 Oct 18.

Abstract

Cellular senescence, characterized by cell cycle arrest, can result in tissue dysfunction when senescent cells persist and accumulate. Periodontitis, a chronic inflammatory condition caused by the interaction between bacteria and the immune system of the host, primarily manifests as damage to periodontal tissues. Aging and inflammation are interlinked processes that exacerbate each other. The progression of localized chronic periodontal inflammation is often accelerated in conjunction with tissue and organ aging. The presence of senescent cells and release of inflammatory cytokines, immune modulators, growth factors and proteases that are associated with the senescence‑associated secretory phenotype contribute to the deterioration of periodontal tissues. The present review aimed to elucidate the mechanisms of cellular senescence and its potential impact on periodontitis, offering novel insights for modulating the inflammatory microenvironment of periodontal tissues.

Keywords: cellular senescence; periodontitis; senescence-associated secretory phenotype.

Publication types

  • Review

MeSH terms

  • Animals
  • Cellular Senescence*
  • Cytokines / metabolism
  • Humans
  • Inflammation / metabolism
  • Inflammation / pathology
  • Periodontitis* / metabolism
  • Periodontitis* / pathology

Substances

  • Cytokines

Grants and funding

The present study was funded by the National Natural Science Foundation of China (grant no. 82201080), the High-level Talents Project of Hainan Natural Science Foundation (grant no. 821RC687) and the Innovative Scientific Research Project for Postgraduates of Hainan Medical College (grant no. Qhys2022-280).