An Assay on the Antibactericidal Functionality of Synthesized Mg-Doped ZnO Nanoparticles on the Dental Microbes

Microsc Res Tech. 2025 Feb;88(2):516-522. doi: 10.1002/jemt.24720. Epub 2024 Oct 25.

Abstract

We succeeded in producing pure and magnesium-doped zinc oxide nanoparticles (Mg-Zn NPs) by making use of a Prosopis farcta leaf extract and subsequently distinguished the quality of our NPs with the use of field energy scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), powder X-ray diffraction (PXRD), and UV-vis. In correlation to our observations, the particulates were spherically produced at a size of 20 nm with the ability to cause antimicrobial impacts on Streptococcus mutans bacteria and Candida albicans fungi. Inhibition zones of 18 ± 0.3 and 24 ± 0.3 mm were obtained for 5% Mg-Zn NPs against bacteria and fungi, respectively. Based on these results, our work suggests a practicable proposition for our synthesized product to be considered as a worthy alternative for dental and oral utilizations.

Keywords: Candida albicans; Streptococcus mutans; magnesium‐doped; zinc oxide nanoparticles.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Candida albicans* / drug effects
  • Magnesium* / chemistry
  • Magnesium* / pharmacology
  • Metal Nanoparticles / chemistry
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Plant Extracts* / chemistry
  • Plant Extracts* / pharmacology
  • Plant Leaves* / chemistry
  • Spectrometry, X-Ray Emission
  • Streptococcus mutans* / drug effects
  • X-Ray Diffraction
  • Zinc Oxide* / chemistry
  • Zinc Oxide* / pharmacology

Substances

  • Zinc Oxide
  • Magnesium
  • Plant Extracts
  • Anti-Bacterial Agents
  • Anti-Infective Agents