Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease

Hannah Roberts; Yimin Fang; Kathleen Quinn; Tiarra Hill; Mackenzie R Peck; Andrzej Bartke; Kevin N Hascup; Erin R Hascup

doi:10.1101/2024.10.15.618508

Lifespan of male and female APP/PS1 and APP^NL-F/NL-F mouse models of Alzheimer's disease

bioRxiv [Preprint]. 2024 Oct 18:2024.10.15.618508. doi: 10.1101/2024.10.15.618508.

Authors

Hannah Roberts¹, Yimin Fang¹, Kathleen Quinn¹, Tiarra Hill¹, Mackenzie R Peck¹, Andrzej Bartke^{2

3}, Kevin N Hascup^{1

3

4}, Erin R Hascup^{1

4}

Affiliations

¹ Neuroscience Institute, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Dept of Neurology; Southern Illinois University School of Medicine, Springfield, IL, USA.
² Dept of Internal Medicine; Southern Illinois University School of Medicine, Springfield, IL, USA.
³ Dept of Medical Microbiology, Immunology and Cell Biology; Southern Illinois University School of Medicine, Springfield, IL, USA.
⁴ Dept of Pharmacology; Southern Illinois University School of Medicine, Springfield, IL, USA.

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP^NL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP^NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.

Keywords: Kaplan-Meier estimate; amyloid-beta; survival curve.

Publication types

Preprint

Abstract

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