Identification of the Novel HLA-DQB1*05:02:01:19 Allele in a Candidate Bone Marrow Donor by Next Generation Sequencing

HLA. 2024 Oct;104(4):e15740. doi: 10.1111/tan.15740.

Abstract

The HLA-DQB1*05:02:01:19 allele differs from HLA-DQB1*05:02:01:01 by a single nucleotide substitution in intron 3.

Keywords: HLA‐DQB1*05:02:01:19 novel allele; Illumina; next generation sequencing.

MeSH terms

  • Alleles*
  • Base Sequence
  • Bone Marrow
  • Bone Marrow Transplantation
  • Exons
  • HLA-DQ beta-Chains* / genetics
  • High-Throughput Nucleotide Sequencing*
  • Histocompatibility Testing* / methods
  • Humans
  • Introns*
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA / methods
  • Tissue Donors*

Substances

  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen