The rs2275738 variant of the adiponectin receptor 1 gene is associated with biopsy-proven nonalcoholic fatty liver disease

Per Med. 2024;21(6):367-372. doi: 10.1080/17410541.2024.2413354. Epub 2024 Oct 29.

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is a significant health issue worldwide. This study investigated the effect of the adiponectin receptor 1 gene (ADIPOR1) polymorphism on susceptibility to NAFLD.Methods: Data from 330 participants, including 165 biopsy-proven NAFLD patients and 165 healthy controls, were collected. The PCR-RFLP method was used to detect the genotypes of ADIPOR1 rs2275738 or T-106C variant.Results: The "CC" genotype of the ADIPOR1 rs2275738 polymorphism, compared with the "TT" genotype and the "C" allele, compared with the "T" allele, are markers of increased NAFLD susceptibility (p = 0.018; OR = 2.07, 95% CI = 1.43-2.01 and p = 0.041; OR = 1.52, 95% CI = 1.24-2.35, respectively).Conclusion: This research suggests, for the first time, that the ADIPOR1 rs2275738 "CC" genotype is associated with a 107% increased risk for biopsy-proven NAFLD.

Keywords: ADIPOR1; NAFLD; adiponectin; adiponectin receptor; nonalcoholic fatty liver disease; polymorphism; rs2275738.

Plain language summary

[Box: see text].

MeSH terms

  • Adult
  • Alleles*
  • Biopsy
  • Case-Control Studies
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease* / genetics
  • Genotype*
  • Humans
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease* / genetics
  • Non-alcoholic Fatty Liver Disease* / pathology
  • Polymorphism, Single Nucleotide* / genetics
  • Receptors, Adiponectin* / genetics

Substances

  • Receptors, Adiponectin
  • ADIPOR1 protein, human