Multidisciplinary approach and host optimization for fracture-related infection management

Injury. 2024 Nov:55 Suppl 6:111899. doi: 10.1016/j.injury.2024.111899.

Abstract

In orthopaedic trauma, fracture-related infections (FRI) are still dreadful challenges that can cause non-union, amputation and even death. Standardization of general treatment strategies for FRI is still lacking. Due to the complexity of FRI, a multidisciplinary approach addressing host status, state of the fracture and causative microorganism has been applied in the management of FRI. Surgical treatment, antibiotic therapy and host optimization for FRI were summarized and discussed. The goal of this review is to provide an overview and summary of current approaches of FRI management and to make suggestions on FRI prevention and treatment based on multidisciplinary principles.

Keywords: Antibiotic therapy; Fracture; Fracture-related infection; Host optimization; Multidisciplinary team; Risk factor; Surgery.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents* / therapeutic use
  • Debridement / methods
  • Fractures, Bone* / complications
  • Fractures, Bone* / therapy
  • Humans
  • Patient Care Team
  • Surgical Wound Infection / prevention & control
  • Surgical Wound Infection / therapy

Substances

  • Anti-Bacterial Agents