Sinonasal Papillomas-An Up-To-Date Review for Practicing Pathologists

William R Perry; Aaron M Udager

doi:10.1016/j.path.2024.07.012

Sinonasal Papillomas-An Up-To-Date Review for Practicing Pathologists

Surg Pathol Clin. 2024 Dec;17(4):561-576. doi: 10.1016/j.path.2024.07.012.

Authors

William R Perry¹, Aaron M Udager²

Affiliations

¹ Department of Pathology, University of Michigan Medical School, 3308 Rogel Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
² Department of Pathology, University of Michigan Medical School, 3308 Rogel Cancer Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: udager@med.umich.edu.

PMID: 39489549
DOI: 10.1016/j.path.2024.07.012

Abstract

Sinonasal papillomas are a group of uncommon benign neoplasms that often represent a diagnostic challenge for surgical pathologists due to their diverse morphologic features. Our understanding of the molecular pathogenesis of these tumors has made significant advances recently that have reinforced the histology-based classification that was introduced over 50 years ago. As some subtypes have features that overlap with other sinonasal tumors, including specific carcinomas such as DEK::AFF2 nonkeratinizing squamous cell carcinoma, being aware of their key diagnostic findings is vital for appropriate classification.

Keywords: Epidermal growth factor receptor (EGFR); Exophytic sinonasal papilloma (ESP); Human papillomavirus (HPV); Inverted sinonasal papilloma (ISP); KRAS; Oncocytic sinonasal papilloma (OSP); Sinonasal squamous cell carcinoma.

Publication types

Review

MeSH terms

Biomarkers, Tumor
Diagnosis, Differential
Humans
Papilloma* / diagnosis
Papilloma* / pathology
Paranasal Sinus Neoplasms* / diagnosis
Paranasal Sinus Neoplasms* / pathology

Substances

Biomarkers, Tumor