History, Advances, and Challenges of Sickle Cell Disease Treatment

Clin Lab Med. 2024 Dec;44(4):679-691. doi: 10.1016/j.cll.2024.07.004. Epub 2024 Sep 20.

Abstract

Sickle cell disease (SCD) is marked by red blood cells that deform into a sickle shape, causing severe health complications. Historic neglect and slow therapeutic progress have left many, especially African descendants, vulnerable. Recent treatment strides include novel drugs and gene therapy, promising improved management. Nonetheless, challenges persist with treatment adoption because of cost, adverse effects, and accessibility. Advancements hold hope for enhanced life quality and longevity for SCD patients.

Keywords: Health equity; Racism; Sickle cell; Treatment advances.

Publication types

  • Review
  • Historical Article

MeSH terms

  • Anemia, Sickle Cell* / therapy
  • Antisickling Agents / therapeutic use
  • Genetic Therapy*
  • History, 20th Century
  • History, 21st Century
  • Humans

Substances

  • Antisickling Agents